A newly published study in Veterinary Microbiology details the successful isolation of contemporary Porcine Sapovirus (PSaV) field strains from commercial swine herds in the United States—an important step forward in understanding this economically relevant enteric virus.
The research was funded by the Swine Health Information Center (SHIC) and conducted by researchers at Ohio State University in collaboration with Veterinary Health Services in Omaha.
SHIC Associate Director Dr. Lisa Becton explains that Porcine Sapovirus affects pigs of all ages, typically causing mild to moderate diarrhea that can lead to reduced weight gain. However, suckling, weaned, and post-weaned pigs appear to be the most susceptible.
Study Findings
As part of the study, five sow farms in Nebraska experiencing gastrointestinal disease outbreaks were sampled. The outbreaks primarily affected pigs between 12 and 18 days of age.
In total:
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35 fecal samples and 7 small intestinal samples were submitted
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All samples were screened for Genogroup-3 Porcine Sapovirus using PCR
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25 of 42 total samples tested positive for PSaV
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Four of the five herds were positive, with herd-level positivity rates ranging from 33 to 100 percent
“A lot of this virus was detected in suckling and post-weaned pigs,” Dr. Becton noted.
The study also utilized next-generation sequencing to evaluate viral changes. Results showed that three of the four positive farms shared genetically similar viruses, while one farm exhibited notable variation in viral composition.
In addition, researchers conducted cell line evaluations to determine which cells could successfully support viral growth—work that could support future diagnostic advancements and vaccine development.
Industry Impact
According to Dr. Becton, the ability to isolate contemporary U.S. field strains provides valuable insight for producers, veterinarians, and researchers working to better understand enteric disease dynamics and improve disease management strategies.
More details on the study are available in SHIC’s January 2026 eNewsletter at swinehealth.org.
