Calves are Susceptible to Infection With the Newly Emerged Porcine Deltacoronavirus

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Archives of Virology, 2017, Volume 162, Number 8, Page 2357

Kwonil Jung, Hui Hu, Linda J. Saif

Food Animal Health Research ProgramOhio Agricultural Research and Development Center, Department of Veterinary Preventive Medicine, The Ohio State UniversityWoosterUSA

College of Animal Science and Veterinary MedicineHenan Agricultural UniversityZhengzhouChina

 

Fecal virus shedding, seroconversion and histopathology were evaluated in 3-7-year-old gnotobiotic calves orally inoculated with porcine deltacoronavirus (PDCoV) (9.0-9.6 log10genomic equivalents [GE] of OH-FD22-P5; n=4) or porcine epidemic diarrhea virus (PEDV) (10.2-12.5 log10 GE of PC21A; n=3). In PDCoV-inoculated calves, an acute but persisting fecal viral RNA shedding and PDCoV-specific serum IgG antibody responses were observed, but without lesions or clinical disease. However, no fecal shedding, seroconversion, histological lesions, and clinical disease were detected in PEDV-inoculated calves. Our data indicate that calves are susceptible to infection by the newly emerged PDCoV, but not by the swine coronavirus, PEDV.

 

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