African Swine Fever Is Spreading Fast and Eliminating It Will Take Decades

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Source: Bloomberg

The deadly pig virus that jumped from Africa to Europe is now ravaging China’s $128 billion pork industry and spreading to other Asian countries, an unprecedented disaster that has prompted Beijing to slaughter millions of pigs. But stopping African swine fever isn’t so easy.

The virus that causes the hemorrhagic disease is highly virulent and tenacious, and spreads in multiple ways. There’s no safe and effective vaccine to prevent infection, nor anything to treat it. The widespread presence in China means it’s now being amplified across a country with 440 million pigs—half the planet’s total—with vast trading networks, permeable land borders and farms with little or no ability to stop animal diseases.

Transcontinental Contagion

How African swine fever spread from Africa to Europe to Asia from 2005 to 2019

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Nigeria: 2005
Zambia: 2006
Kenya: 2006
Burkina Faso: 2007
Georgia: 2007
Armenia: 2007
Mauritius: 2007
Russia: 2007
Azerbaijan: 2008
Tanzania: 2008
Namibia: 2008
Central African Republic: 2010
Chad: 2010
South Africa: 2012
Ukraine: 2012
Belarus: 2013
Benin: 2013
Lithuania: 2014
Poland: 2014
Cote D’Ivoire: 2014
Latvia: 2014
Estonia: 2014
Cape Verde: 2015
Zimbabwe: 2015
Mali: 2016
Burundi: 2016
Moldova: 2016
Czech Republic: 2017
Romania: 2017
Hungary: 2018
China: 2018
Bulgaria: 2018
Belgium: 2018
Mongolia: 2019
Vietnam: 2019
Cambodia: 2019
Hong Kong: 2019
North Korea: 2019

Source: OIE, as of May 23 2019

The number of pigs China will fatten this year is predicted to fall by 134 million, or 20%, from 2018—the worst annual slump since the U.S. Department of Agriculture began counting China’s pigs in the mid-1970s. While the pig virus doesn’t harm humans even if they eat tainted pork, the fatality rate in pigs means it could destroy the region’s pork industry.

Culling in China

1.1 million

Hogs officially culled so far to stop the spread of the virus…

Estimates based on previous outbreaks

indicate that the final number for the year could be as high as 200 million slaughtered hogs

…in comparison to an estimated

250 million

poultry culled in 1996 for avian flu

Source: Bloomberg Data

Spain’s experience with the disease suggests that a cull alone won’t be enough to solve the problem. The country implemented strict sanitary measures and industrialized its hog production system but it took 35 years and help from the European Union before the disease was eradicated in 1995. The Italian island of Sardinia has been trying unsuccessfully to get rid of the virus for four decades, and its hog population is a fraction of China’s.

Multiple Routes

Main sources of African swine fever into Europe

Raw pork waste at airport or port

Movement of pork or pig product

Natural ranging of infected wild boar

Infected ticks

Belgium

1985

Georgia

2007

Russia

2007

Estonia

2014

Sardinia

1978

Italy

1983

Portugal

1999

Portugal

1960

Lisbon

1957

Lithuania

2014

Malta

1978

Spain

1960

Belgium

2018

Poland

2014

Source: J.M. Sánchez-Vizcaíno, et al, 2014, OIE
Mystery Source

One of the reasons why African swine fever is so hard to eradicate is that it’s easy to transmit. In addition to direct contact with an infected pig, the virus can be passed on to animals that eat virus-laden pork or feed, via contaminated clothing or equipment or when a pig drinks water containing even minute quantities of the virus.Studies show that the strain in China closely resembles one that’s been spreading in Russia and other parts of Europe for more than a decade. But scientists still don’t know the route it took to get into the world’s most populous nation. Without knowing how the virus got in, China’s customs officials will have a harder time preventing repeated introductions.

The disease is now in Mongolia, Vietnam, North Korea and possibly other neighboring countries that lack the resources to identify and control the disease. That increases the risk that, even if China does manage to control the disease domestically, it could re-enter the country via people or pork products that cross the border.

A pork stall at a market in Hanoi, Vietnam
A pork stall at a market in Hanoi, Vietnam. Photographer: Yen Duong/Bloomberg
Dirty Garbage

Scientists say the virus may have arrived in China the same way it entered Europe in early 2007. A United Nations report suggests some food-waste containing pork was dumped from a ship visiting the port of Poti on the Georgian Black Sea and then eaten by one of the local pigs that are allowed to scavenge on garbage. Within weeks, 30,000 pigs had died and 80 percent of Georgia’s districts were thought to be infected.Pigs and their feral wild-boar cousins are quintessential waste disposal units, guzzling on protein from a wide variety of sources, including kitchen scraps, manure and dead hogs. While the omnivorous nature of the animals makes them low-cost nutrient converters, it’s also a key reason that African swine fever spreads easily.

A review of outbreaks showed that almost half were caused by the spread of virus material on vehicles and on non-disinfected workers, with feeding pigs contaminated swill or food scraps the second-biggest source. Feeding raw swill to pigs has been outlawed in China because of the risk of disease transmission, but clandestine use of non-heat-treated restaurant and household waste is reported to persist among suburban and smallholder farmers. About half of China’s producers raise fewer than 500 hogs each.

Sticky Germs

Epidemiological studies of 68 outbreaks in China revealed three major causes of spread

68

outbreaks

46%

34%

19%

Virus carried on

vehicles and workers

without disinfection

Feeding pigs swill

Transportation

of live pigs and

their products

Source: China’s Ministry of Agriculture and Rural Affairs

So far, government efforts to halt the spread through quarantining and sanitizing infected farms, culling vulnerable pigs, closing markets and restricting the movement of hogs have been insufficient, and the disease has become entrenched across the country.

Surreptitious

The virus is also hard to track. Pigs may incubate it for five to 15 days and can shed infectious particles for one to two days before falling ill. That means the virus can be silently spread in the waste, meat and blood of infected pigs that don’t appear to be sick, especially when they are illegally transported or slaughtered before diagnosis.In China, pigs are routinely trucked hundreds of miles as farmers and traders seek to take advantage of regional differences in livestock and meat availability and prices, as well as a preference for fresh meat. When hogs arrive at a new farm, they are typically mixed immediately with other swine, facilitating transmission of the disease.

Hiding Outbreaks

Identifying outbreaks early is critical for mitigating their spread. The Chinese government has pledged to pay a subsidy of 1,200 yuan per pig to compensate farms for losses, but some local governments are reported to be withholding payments—removing an incentive for farmers to report the disease.In some instances, individuals have even been punished for publicizing outbreaks. A hog manager in Shandong province was allegedly arrested for reporting infected pigs to the national government after his efforts to alert local officials were ignored.

Saturated Blood

The virus, though, doesn’t need traveling swine to spread. A single drop from an acutely infected pig can contain 50 million virus particles, and just one of those particles ingested in contaminated drinking water may be enough to transfer the disease to another pig.

Infected blood, or fluids from urine, saliva or feces, can be carried in dirt on truck tires and shoes, allowing the disease to travel hundreds of miles quite rapidly. Contaminated sources require heating to 60 degrees Celsius (140 Fahrenheit) for 30 minutes to be rendered safe.

Tens of thousands of swine have been infected in China and their carcasses represent an enormous environmental risk, requiring careful handling and disposal. In Romania, the contamination of the Danube River from dead hogs was implicated in the virus’s spread to a 140,000-pig farm.

Tough Survivor

The germ is hardy, capable of remaining active in water for a month, in meat and blood at room temperature for several months and for six years in cold, dark conditions. It’s resistant to temperature extremes, and can survive a day in vinegar-strength acids.

Stealthy Bug

African swine fever can survive temperature and pH extremes

Pork products

Other media

0

1

2

3

4

5

6 Years

15 minutes in unprocessed meat heated to 70°C (158°F)

3.5 hours at 56°C

22 hours at pH 3.1 (an acidity similar to vinegar)

3 days in feces at room temperature

5 days in feces at 4-10°C

5 days in urine

5 days in cooked ham

5 days in animal feed at room temperature

16 days in organs at room temperature

25 days in slurry

30 days in pepperoni and salami sausage

30 days in pigs that survive infection

60 days in canned stew

60 days in water at room temperature

104 days in frozen meat or chilled meat

112 days in Iberian loins

140 days in Iberian hams and white Serrano hams

399 days in Parma hams

525 days in blood at 4-10°C

More than 2 years in frozen pig organs

6 years at 5°C with no light

Sources: OIE, M.C. Niederwerder et al, S. Farez et al, K. Davies et al, European Food Safety Authority

There are no published studies reporting the incidence of African swine fever virus detected in food in China. But the virus has been in Chinese pork products that were confiscated by customs officials in Japan, South Korea and Australia, suggesting that the virus has permeated the food chain in China.

Even if China is able to stop the virus transmitting from pig to pig, two other disease vectors may frustrate eradication efforts: wild boars and Ornithodoros ticks. These are the natural hosts of African swine fever virus and are widely distributed in China, though it’s not yet known what role they are playing in spreading the disease there. Zhejiang province, south of Shanghai, has about 150,000 wild boars.

A pork stall at a market in Hanoi, Vietnam
Workers in protective gear spray disinfectants at a pig farm in Jinhua, Zhejiang province, China, on Aug. 22, 2018. Source: VCG via Getty Images
No Vaccine

Despite 50 years of research, scientists haven’t managed to develop a vaccine that’s safe and effective against African swine fever, and even if recent research proves fruitful, it could be years before an effective shot becomes commercially available.One of the earliest attempts—based on a live, weakened form of the virus—was abandoned after it was found the vaccine gave pigs a debilitating and disfiguring disease.

Studies have found that the animals which recover from an initial African swine fever infection are resistant to some other strains, but scientists aren’t sure what exactly confers that protection or how best to evaluate the potential efficacy of candidate vaccines.

One of their difficulties is that the large, complex DNA virus that causes African swine fever has some 170 genes and 80 proteins, many of them specialized in evading different aspects of the pig immune system.

More recent attempts to produce an immunization using viruses that lack key disease-causing genes appear to be safe. Still, researchers are yet to carry out large field trials to demonstrate effectiveness in commercial farms—a necessary step for gaining regulatory approval. That may delay the availability of game-changing vaccines for years.

With a tough virus to eradicate and no vaccine on the horizon, the best way China can protect its domestic pork industry from African swine fever is to carefully monitor and control the germs on every pig, person and product entering and leaving hog farms. That would mean turning China’s 26 million piggeries into veritable biocontainment facilities.

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